Role of Metabotropic Glutamate Receptors in Neurological Disorders

Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity. Moreover, excessive glutamate release has been implicated in neuronal cell death. There are both ionotropic and metabotrop...

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Bibliographic Details
Main Authors: Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00020/full