Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatus

Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatus

ABSTRACT Aspergillus fumigatus is the major filamentous fungal pathogen in humans. The gold standard treatment of A. fumigatus is based on azole drug use, but the appearance of azole-resistant isolates is increasing at an alarming rate. The cyp51A gene encodes the enzymatic target of azole drugs, an...

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Bibliographic Details
Main Authors: Sanjoy Paul, Paul E. Verweij, Willem J. G. Melchers, W. Scott Moye-Rowley
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
Aspergillus fumigatus
azole resistance
drug resistance mechanisms
mutational studies
promoters
transcription factors
Online Access:https://journals.asm.org/doi/10.1128/mbio.00702-22

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https://journals.asm.org/doi/10.1128/mbio.00702-22

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