Rapidly Inhibiting the Inflammatory Cytokine Storms and Restoring Cellular Homeostasis to Alleviate Sepsis by Blocking Pyroptosis and Mitochondrial Apoptosis Pathways

Abstract Pyroptosis, systemic inflammation, and mitochondrial apoptosis are the three primary contributors to sepsis's multiple organ failure, the ultimate cause of high clinical mortality. Currently, the drugs under development only target a single pathogenesis, which is obviously insufficient...

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Bibliographic Details
Main Authors: Jiahui Yan, Jingwen Zhang, Yanan Wang, Hong Liu, Xueping Sun, Aixin Li, Pengfei Cui, Liangmin Yu, Xuefeng Yan, Zhiyu He
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.202207448