The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study
Moderate red wine intake has been associated with lower cardiovascular mortality, due in part to the intake of polyphenols and anthocyanins, whose content can vary from varietal and year of harvest. This study assessed the vascular effects in response to a single intake of 2015 and 2018 Zweigelt red...
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/4054 |
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| author | Prae Charoenwoodhipong Roberta R. Holt Carl L. Keen Nasim Hedayati Tomoyuki Sato Teruo Sone Robert M. Hackman |
| author_facet | Prae Charoenwoodhipong Roberta R. Holt Carl L. Keen Nasim Hedayati Tomoyuki Sato Teruo Sone Robert M. Hackman |
| author_sort | Prae Charoenwoodhipong |
| collection | DOAJ |
| description | Moderate red wine intake has been associated with lower cardiovascular mortality, due in part to the intake of polyphenols and anthocyanins, whose content can vary from varietal and year of harvest. This study assessed the vascular effects in response to a single intake of 2015 and 2018 Zweigelt red wines from Hokkaido, Japan. Healthy men were randomly assigned to consume 240 mL each of a red wine, or a sparkling white grape juice as a control in a randomized three-arm cross-over design with a 7 day washout between arms. The augmentation index (AI; a measure of arterial stiffness) and AI at 75 beats/min (AI75), reactive hyperemia index, systolic and diastolic blood pressure (SBP and DBP, respectively), and platelet reactivity were assessed at baseline and two and four hours after each beverage intake. Changes from the baseline were analyzed using a linear mixed model. Significant treatment effects (<i>p</i> = 0.02) were observed, with AI 13% lower after the intake of the 2015 or 2018 vintages compared to the control. Intake of the 2018 vintage reduced SBP and DBP (−4.1 mmHg and −5.6 mmHg, respectively; <i>p</i> = 0.02) compared to the 2015 wine and the control drink. The amount of hydroxytyrosol in the 2018 wine was almost twice the amount as in the 2015 wine, which may help explain the variable blood pressure results. Future studies exploring the vascular effects of the same red wine from different vintage years and different phenolic profiles are warranted. |
| first_indexed | 2024-03-10T22:19:07Z |
| format | Article |
| id | doaj.art-2d9ecc1636174d71bab5c850a49a8ba1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:19:07Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2d9ecc1636174d71bab5c850a49a8ba12023-11-19T12:19:43ZengMDPI AGNutrients2072-66432023-09-011518405410.3390/nu15184054The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot StudyPrae Charoenwoodhipong0Roberta R. Holt1Carl L. Keen2Nasim Hedayati3Tomoyuki Sato4Teruo Sone5Robert M. Hackman6Department of Nutrition, University of California Davis, Davis, CA 95616, USADepartment of Nutrition, University of California Davis, Davis, CA 95616, USADepartment of Nutrition, University of California Davis, Davis, CA 95616, USADivision of Vascular Surgery, Department of Surgery, University of California Davis, Sacramento, CA 95817, USAResearch Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Hokkaido, JapanResearch Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Hokkaido, JapanDepartment of Nutrition, University of California Davis, Davis, CA 95616, USAModerate red wine intake has been associated with lower cardiovascular mortality, due in part to the intake of polyphenols and anthocyanins, whose content can vary from varietal and year of harvest. This study assessed the vascular effects in response to a single intake of 2015 and 2018 Zweigelt red wines from Hokkaido, Japan. Healthy men were randomly assigned to consume 240 mL each of a red wine, or a sparkling white grape juice as a control in a randomized three-arm cross-over design with a 7 day washout between arms. The augmentation index (AI; a measure of arterial stiffness) and AI at 75 beats/min (AI75), reactive hyperemia index, systolic and diastolic blood pressure (SBP and DBP, respectively), and platelet reactivity were assessed at baseline and two and four hours after each beverage intake. Changes from the baseline were analyzed using a linear mixed model. Significant treatment effects (<i>p</i> = 0.02) were observed, with AI 13% lower after the intake of the 2015 or 2018 vintages compared to the control. Intake of the 2018 vintage reduced SBP and DBP (−4.1 mmHg and −5.6 mmHg, respectively; <i>p</i> = 0.02) compared to the 2015 wine and the control drink. The amount of hydroxytyrosol in the 2018 wine was almost twice the amount as in the 2015 wine, which may help explain the variable blood pressure results. Future studies exploring the vascular effects of the same red wine from different vintage years and different phenolic profiles are warranted.https://www.mdpi.com/2072-6643/15/18/4054red winevascular functionblood pressureanthocyaninspolyphenolsarterial stiffness |
| spellingShingle | Prae Charoenwoodhipong Roberta R. Holt Carl L. Keen Nasim Hedayati Tomoyuki Sato Teruo Sone Robert M. Hackman The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study Nutrients red wine vascular function blood pressure anthocyanins polyphenols arterial stiffness |
| title | The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study |
| title_full | The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study |
| title_fullStr | The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study |
| title_full_unstemmed | The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study |
| title_short | The Effect of Hokkaido Red Wines on Vascular Outcomes in Healthy Adult Men: A Pilot Study |
| title_sort | effect of hokkaido red wines on vascular outcomes in healthy adult men a pilot study |
| topic | red wine vascular function blood pressure anthocyanins polyphenols arterial stiffness |
| url | https://www.mdpi.com/2072-6643/15/18/4054 |
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