Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7)

Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7)

The n-3 fatty acid α-linolenic acid (ALA) inhibits oestrogen receptor (ER) positive MCF-7 cell growth in vitro and in vivo. Our objective was to explore potential mechanisms. MCF-7 cells were treated with 100 µM ALA and 1 nM oestradiol (E2) then analysed for fatty acid profile, mRNA and protein biom...

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Bibliographic Details
Main Authors: Julie K. Mason-Ennis, Lauren P. LeMay-Nedjelski, Ashleigh K.A. Wiggins, Lilian U. Thompson
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Functional Foods
Subjects:
Breast cancer
α-linolenic acid
n-3 fatty acid
Oestrogen receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616301128

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