Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study
OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT...
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| Format: | Article |
| Language: | English |
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AVES
2018-04-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
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| Online Access: | http://dx.doi.org/10.1080/24750573.2017.1418134 |
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| author | Aynur Pekcanlar Akay Çiğdem Eresen Yazıcıoğlu Sevay Alşen Güney Handan Özek Erkuran Sefa Kızıldağ Burak Baykara Gonca Özyurt Şebnem Yıldırımcan Kadıçeşme Süha Miral Neslihan İnal Emiroğlu |
| author_facet | Aynur Pekcanlar Akay Çiğdem Eresen Yazıcıoğlu Sevay Alşen Güney Handan Özek Erkuran Sefa Kızıldağ Burak Baykara Gonca Özyurt Şebnem Yıldırımcan Kadıçeşme Süha Miral Neslihan İnal Emiroğlu |
| author_sort | Aynur Pekcanlar Akay |
| collection | DOAJ |
| description | OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT) genes. METHODS: Thirty-four adolescents (age range, 13–18 years) with ADHD participated in this study. Thirty-two patients were males and two were females. Du Paul ADHD Rating Scale-Clinician version (ARS) and Clinical Global Impression-severity of impairment (CGI-S) were used for the evaluation of symptom severity. Fifty healthy age-matched adolescents were recruited as controls. RESULTS: When the groups with (n = 9) and without (n = 25) 7-repeat alleles for DRD4 were considered, there was a statistically significant decrease of DuPaul ARS total and hyperactivity scores in those treated with OROS-methylphenidate. When the Val/Met allele-positive group for COMT gene (n = 17) was compared with the Val/Val allele-positive group (n = 13) and Met/Met allele-positive group (n = 4), there was a statistically significant decrease of ARS total scores, ARS attention scores, and CGI scores in adolescents with ADHD treated with OROS-MPH. CONCLUSIONS: Specific data from further studies with a larger sample sizes would provide more insights to replicate the current findings. |
| first_indexed | 2024-04-10T13:22:12Z |
| format | Article |
| id | doaj.art-2da2d57875fe4774a2ab28d8cc17ce3a |
| institution | Directory Open Access Journal |
| issn | 2475-0573 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T13:22:12Z |
| publishDate | 2018-04-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-2da2d57875fe4774a2ab28d8cc17ce3a2023-02-15T16:12:00ZengAVESPsychiatry and Clinical Psychopharmacology2475-05732475-05812018-04-0128217718410.1080/24750573.2017.14181341418134Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary studyAynur Pekcanlar Akay0Çiğdem Eresen Yazıcıoğlu1Sevay Alşen Güney2Handan Özek Erkuran3Sefa Kızıldağ4Burak Baykara5Gonca Özyurt6Şebnem Yıldırımcan Kadıçeşme7Süha Miral8Neslihan İnal Emiroğlu9Dokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityChild Psychiatry Specialist, Dr. Behçet Uz Pediatrics and Pediatric Surgery Training HospitalDokuz Eylul UniversityDokuz Eylul UniversityKatip Çelebi University Medical FacultyDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityOBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT) genes. METHODS: Thirty-four adolescents (age range, 13–18 years) with ADHD participated in this study. Thirty-two patients were males and two were females. Du Paul ADHD Rating Scale-Clinician version (ARS) and Clinical Global Impression-severity of impairment (CGI-S) were used for the evaluation of symptom severity. Fifty healthy age-matched adolescents were recruited as controls. RESULTS: When the groups with (n = 9) and without (n = 25) 7-repeat alleles for DRD4 were considered, there was a statistically significant decrease of DuPaul ARS total and hyperactivity scores in those treated with OROS-methylphenidate. When the Val/Met allele-positive group for COMT gene (n = 17) was compared with the Val/Val allele-positive group (n = 13) and Met/Met allele-positive group (n = 4), there was a statistically significant decrease of ARS total scores, ARS attention scores, and CGI scores in adolescents with ADHD treated with OROS-MPH. CONCLUSIONS: Specific data from further studies with a larger sample sizes would provide more insights to replicate the current findings.http://dx.doi.org/10.1080/24750573.2017.1418134Attention deficit/hyperactivity disorderadolescentscatechol-O-methyltransferase gene (COMT)dopamine D4 receptor gene (DRD4)methylphenidateclinical global impression (CGI) |
| spellingShingle | Aynur Pekcanlar Akay Çiğdem Eresen Yazıcıoğlu Sevay Alşen Güney Handan Özek Erkuran Sefa Kızıldağ Burak Baykara Gonca Özyurt Şebnem Yıldırımcan Kadıçeşme Süha Miral Neslihan İnal Emiroğlu Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study Psychiatry and Clinical Psychopharmacology Attention deficit/hyperactivity disorder adolescents catechol-O-methyltransferase gene (COMT) dopamine D4 receptor gene (DRD4) methylphenidate clinical global impression (CGI) |
| title | Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study |
| title_full | Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study |
| title_fullStr | Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study |
| title_full_unstemmed | Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study |
| title_short | Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study |
| title_sort | allele frequencies of dopamine d4 receptor gene drd4 and catechol o methyltransferase comt val158met polymorphism are associated with methylphenidate response in adolescents with attention deficit hyperactivity disorder a case control preliminary study |
| topic | Attention deficit/hyperactivity disorder adolescents catechol-O-methyltransferase gene (COMT) dopamine D4 receptor gene (DRD4) methylphenidate clinical global impression (CGI) |
| url | http://dx.doi.org/10.1080/24750573.2017.1418134 |
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