Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.

Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.

Oncogenes induce cell proliferation leading to replicative stress, DNA damage and genomic instability. A wide variety of cellular stresses activate c-Jun N-terminal kinase (JNK) proteins, but few studies have directly addressed the roles of JNK isoforms in tumor development. Herein, we show that jnk...

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Bibliographic Details
Main Authors: Peila Chen, Jamye F O'Neal, Nancy D Ebelt, Michael A Cantrell, Shreya Mitra, Azadeh Nasrazadani, Tracy L Vandenbroek, Lynn E Heasley, Carla L Van Den Berg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2862739?pdf=render

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http://europepmc.org/articles/PMC2862739?pdf=render

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