A bone to pick-cellular and molecular mechanisms of bone pain in sickle cell disease

A bone to pick-cellular and molecular mechanisms of bone pain in sickle cell disease

The bone is one of the most commonly affected organs in sickle cell disease (SCD). Repeated ischemia, oxidative stress and inflammation within the bone is largely responsible for promoting bone pain. As more individuals with SCD survive into adulthood, they are likely to experience a synergistic imp...

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Bibliographic Details
Main Authors: Jahnavi Gollamudi, Kristine A. Karkoska, Oluwabukola T. Gbotosho, Wei Zou, Hyacinth I. Hyacinth, Steven L. Teitelbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pain Research
Subjects:
sickle cell disease
pain
nervous system
inflammation
bone remodeling
hemolytic anemia
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2023.1302014/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2023.1302014/full

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