SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization

SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization

ABSTRACTStreptococcus pneumoniae (Spn), a Gram-positive bacterium, is responsible for causing a wide variety of invasive infections. The emergence of multi-drug antibiotic resistance has prompted the search for antimicrobial alternatives. Phage-derived peptidoglycan hydrolases, known as endolysins,...

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Bibliographic Details
Main Authors: Adit B. Alreja, Amanda E. Appel, Jinyi C. Zhu, Sean P. Riley, Norberto Gonzalez-Juarbe, Daniel C. Nelson
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
endolysin
CHAP domain
bacteriophage
pneumococcus
antibiotic resistance
Online Access:https://journals.asm.org/doi/10.1128/mbio.00069-24

Internet

https://journals.asm.org/doi/10.1128/mbio.00069-24

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