Prospective validation study: a non-invasive circulating tumor DNA-based assay for simultaneous early detection of multiple cancers in asymptomatic adults

Prospective validation study: a non-invasive circulating tumor DNA-based assay for simultaneous early detection of multiple cancers in asymptomatic adults

Abstract Background Non-invasive multi-cancer early detection (MCED) tests have shown promise in enhancing early cancer detection. However, their clinical utility across diverse populations remains underexplored, limiting their routine implementation. This study aims to validate the clinical utility...

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Main Authors: Luu Hong Dang Nguyen, Thi Hue Hanh Nguyen, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Ngoc Minh Phan, Ba Linh Tieu, Giang Thi Huong Nguyen, Dac Ho Vo, Trung Hieu Tran, Thanh Dat Nguyen, Van Thien Chi Nguyen, Trong Hieu Nguyen, Vu Uyen Tran, Minh Phong Le, Thi Minh Thu Tran, Minh Nguyen Nguyen, Thi Tuong Vi Van, Anh Nhu Nguyen, Thi Thanh Nguyen, Nhu Nhat Tan Doan, Hoang Tan Nguyen, Phuoc Loc Doan, Le Anh Khoa Huynh, Tien Anh Nguyen, Huu Tam Phuc Nguyen, Y.-Thanh Lu, Chi Thuy Tien Cao, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan-Anh Luong, Thi Kim Phuong Doan, Thi Trang Dao, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Duy Sinh Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh Kiet Truong, Hung Sang Tang, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medicine
Subjects:
Liquid biopsy
Multimodal analysis
Multicancer early detection
Tissue of origin
Clinical validation
Online Access:https://doi.org/10.1186/s12916-025-03929-y

Internet

https://doi.org/10.1186/s12916-025-03929-y

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