Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects.

Targeted nanoparticle delivery is a promising strategy for increasing efficacy and limiting side effects of therapeutics. When designing a targeted liposomal formulation, the in vivo biodistribution of the particles must be characterized to determine the value of the targeting approach. Peroxisome p...

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Bibliographic Details
Main Authors: Dustin K Bauknight, Victoria Osinski, Siva Sai Krishna Dasa, Anh T Nguyen, Melissa A Marshall, Julia Hartman, Matthew Harms, Gavin O'Mahony, Jeremie Boucher, Alexander L Klibanov, Coleen A McNamara, Kimberly A Kelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0224917

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