A neurodevelopmental TUBB2B β-tubulin mutation impairs Bim1 (yeast EB1)-dependent spindle positioning

A neurodevelopmental TUBB2B β-tubulin mutation impairs Bim1 (yeast EB1)-dependent spindle positioning

Malformations of the human cerebral cortex can be caused by mutations in tubulins that associate to compose microtubules. Cerebral cortical folding relies on neuronal migration and on progenitor proliferation partly dictated by microtubule-dependent mitotic spindle positioning. A single amino acid c...

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Bibliographic Details
Main Authors: Eric Denarier, Carine Brousse, Abdoulaye Sissoko, Annie Andrieux, Cécile Boscheron
Format: Article
Language:English
Published: The Company of Biologists 2019-01-01
Series:Biology Open
Subjects:
EB1
Microtubule
Spindle positioning
TUBB2B
Yeast
Online Access:http://bio.biologists.org/content/8/1/bio038620

Internet

http://bio.biologists.org/content/8/1/bio038620

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