Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor immunity

Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor immunity

Abstract CD80 is an important co‐stimulatory molecule that participates in the immune response. Soluble CD80 can induce T cell activation and overcome PDL1‐mediated immune suppression. In this study, we aimed to construct recombinant Lactococcus lactis for oral delivery of the soluble CD80 (hsCD80)...

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Bibliographic Details
Main Authors: Ziqing Lin, Yanqing Tang, Zerong Chen, Simin Li, Xueyan Xu, Xufeng Hou, Zhenhui Chen, Junjie Wen, Weisen Zeng, Xiaojing Meng, Hongying Fan
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Bioengineering & Translational Medicine
Subjects:
cholera toxin B subunit (CTB)
human soluble CD80
lactic acid bacteria
tumor therapy
Online Access:https://doi.org/10.1002/btm2.10533

Internet

https://doi.org/10.1002/btm2.10533

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