RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy. Here we demonstrate the utility of MiXCR software for TCR and immunoglobulin repertoire extraction from RNA-Seq data obtained...

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Bibliographic Details
Main Authors: Ekaterina A. Zhigalova, Anna I. Izosimova, Diana V. Yuzhakova, Lilia N. Volchkova, Irina A. Shagina, Maria A. Turchaninova, Ekaterina O. Serebrovskaya, Elena V. Zagaynova, Dmitriy M. Chudakov, George V. Sharonov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
tumor-infiltrating lymphocytes
TCR repertoire
RNA-Seq
anti-PD-1
T cell clonality
MiXCR
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00385/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00385/full

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