Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality

Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality

Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to ceramide-1-phosphate (C1P) by ceramide kinase (CerK). The CerK/C1P pathway regulates many cellular functions, but its roles in immune/inflammation-related (IIR) diseases in vivo are not well known. Sepsis is an acute syste...

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Bibliographic Details
Main Authors: Ai Tanaka, Takuya Honda, Masataka Yasue, Risa Yamazaki, Hiroto Hatakeyama, Akihiro Hisaka, Masato Mashimo, Takafumi Kohama, Hiroyuki Nakamura, Toshihiko Murayama
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Ceramide-1-phosphate
Neutrophils
Interleukin-17
Tumor necrosis factor-α
Monocyte chemotactic protein-1 (MCP-1)
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000457

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http://www.sciencedirect.com/science/article/pii/S1347861322000457

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