Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus

Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus

We mapped the hemagglutinin-esterase (HE) antigenic epitopes of the influenza C virus on the three-dimensional (3D) structure of the HE glycoprotein using 246 escape mutants that were selected by a panel of nine anti-HE monoclonal antibodies (MAbs), including seven of the C/Ann Arbor/1/50 virus and...

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Bibliographic Details
Main Authors: Yoko Matsuzaki, Kanetsu Sugawara, Yuki Furuse, Yoshitaka Shimotai, Seiji Hongo, Katsumi Mizuta, Hidekazu Nishimura
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Viruses
Subjects:
influenza C virus
escape mutant
antigenic structure
epidemiology
Online Access:http://www.mdpi.com/1999-4915/10/8/417

Internet

http://www.mdpi.com/1999-4915/10/8/417

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