Before Direct-Acting Antivirals for Hepatitis C Virus: Evaluation of Core Protein R70Q and L/C91M Substitutions in Chronically Infected Brazilian Patients Unresponsive to IFN and/or RBV

Before Direct-Acting Antivirals for Hepatitis C Virus: Evaluation of Core Protein R70Q and L/C91M Substitutions in Chronically Infected Brazilian Patients Unresponsive to IFN and/or RBV

Although chronic hepatitis C has been effectively treated with direct-acting antivirals (DAAs), the use of conventional therapy with peg-interferon (Peg-IFN) or (predominantly) ribavirin (RBV), remains widespread. R70Q/H and L/C91M amino acid substitutions in the hepatitis C virus (HCV) core protein...

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Bibliographic Details
Main Authors: Letícia Bomfim Campos, Nathália Alves Araújo de Almeida, Catarina Góis de Santana, Evorah Nascimento Pereira Barbosa, Marco Aurelio Pereira Horta, Márcia Amendola Pires, Carlos Eduardo Brandão Mello, Vanessa Salete de Paula, José Júnior França de Barros
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
chronic hepatitis C
non-sustained viral response
amino acid substitutions R70Q/H and L/C91M
clinical and epidemiological profiles
host risk factors
subpopulations
Online Access:https://www.mdpi.com/1999-4915/15/1/187

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https://www.mdpi.com/1999-4915/15/1/187

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