Coupling Bulk Phase Separation of Disordered Proteins to Membrane Domain Formation in Molecular Simulations on a Bespoke Compute Fabric

Coupling Bulk Phase Separation of Disordered Proteins to Membrane Domain Formation in Molecular Simulations on a Bespoke Compute Fabric

Phospholipid membranes surround the cell and its internal organelles, and their multicomponent nature allows the formation of domains that are important in cellular signalling, the immune system, and bacterial infection. Cytoplasmic compartments are also created by the phase separation of intrinsica...

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Bibliographic Details
Main Authors: Julian C. Shillcock, David B. Thomas, Jonathan R. Beaumont, Graeme M. Bragg, Mark L. Vousden, Andrew D. Brown
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Membranes
Subjects:
membrane domains
intrinsically-disordered protein
phase separation
biomolecular condensate
coarse-grained simulation
event-based computing
Online Access:https://www.mdpi.com/2077-0375/12/1/17

Internet

https://www.mdpi.com/2077-0375/12/1/17

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