RUNX3 mediates keloid fibroblast proliferation through deacetylation of EZH2 by SIRT1

RUNX3 mediates keloid fibroblast proliferation through deacetylation of EZH2 by SIRT1

Abstract Background Keloid is a benign proliferative fibrous disease featured by excessive fibroblast proliferation after skin injury. However, the mechanism of abnormal cell proliferation is still unclear. Herein, we investigated the mechanism of abnormal proliferation in keloids involving Sirtuin...

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Bibliographic Details
Main Authors: Hanye Liu, Guanghai Yan, Li Li, Dandan Wang, Yu Wang, Shan Jin, Zhehu Jin, Liangchang Li, Lianhua Zhu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Molecular and Cell Biology
Subjects:
Keloid
Abnormal proliferation
Cell cycle
SIRT1/EZH2/RUNX3 axis
Online Access:https://doi.org/10.1186/s12860-022-00451-4

Internet

https://doi.org/10.1186/s12860-022-00451-4

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