Impact of a conserved N-terminal proline-rich region of the α-subunit of CAAX-prenyltransferases on their enzyme properties

Impact of a conserved N-terminal proline-rich region of the α-subunit of CAAX-prenyltransferases on their enzyme properties

Abstract Background The CAAX-prenyltransferases farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) are heterodimers with a common α- (FTα) and unique β-subunits. Recently, α-subunits of species (e.g., human) that harbour an N-terminal proline-rich region (PRR) showed different di...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Anna Hagemann, Sandro Tasillo, Aykut Aydin, Miriam Caroline Alice Kehrenberg, Hagen Sjard Bachmann
स्वरूप: लेख
भाषा:English
प्रकाशित: BMC 2022-08-01
श्रृंखला:Cell Communication and Signaling
विषय:
Human Farnesyltransferase
Proline-rich region
Interaction
Homodimer
Heterodimer
Prenylation
ऑनलाइन पहुंच:https://doi.org/10.1186/s12964-022-00929-w

इंटरनेट

https://doi.org/10.1186/s12964-022-00929-w

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