IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2

IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2

Summary: The prognosis of glioblastoma (GBM) patients is poor, and temozolomide (TMZ) resistance has become an important obstacle to its treatment effect. A growing number of researches have revealed the special characteristics of iron metabolism in GBM chemosensitivity. Iron regulatory protein 1 (I...

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Bibliographic Details
Main Authors: Yufei Lan, Tao Yang, Qu Yue, Zhao Wang, Xiangyang Zhong, Xin Luo, Boming Zuo, Manqing Zhang, Tianci Zeng, Boyang Liu, Hongbo Guo
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Oncology
Biological sciences
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014542

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http://www.sciencedirect.com/science/article/pii/S2589004223014542

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