The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes.

The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes.

BACKGROUND: Celiac disease is a T-cell mediated chronic inflammatory disorder of the gut that is induced by dietary exposure to gluten proteins. CD4+ T cells of the intestinal lesion recognize gluten peptides in the context of HLA-DQ2.5 or HLA-DQ8 and the gluten derived peptides become better T-cell...

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Bibliographic Details
Main Authors: Siri Dørum, Magnus Ø Arntzen, Shuo-Wang Qiao, Anders Holm, Christian J Koehler, Bernd Thiede, Ludvig M Sollid, Burkhard Fleckenstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2988817?pdf=render

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http://europepmc.org/articles/PMC2988817?pdf=render

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