Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity

Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity

Abstract Background Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of Parkinson’s disease (PD), even prior to dopaminergic neuron degeneration in the substantia nigra (SN),...

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Bibliographic Details
Main Authors: Daniel Torrente, Enming J. Su, Gerald P. Schielke, Mark Warnock, Kris Mann, Daniel A. Lawrence
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
α-Synuclein
Substantia nigra
Parkinson disease
Dopaminergic neurons
Propranolol
Clenbuterol
Online Access:https://doi.org/10.1186/s12974-023-02748-3

Internet

https://doi.org/10.1186/s12974-023-02748-3

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