Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is subjected to multiple post-translational modifications which r...

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Bibliographic Details
Main Authors: Fanny L. Lemarié, Shaun S. Sanders, Yen Nguyen, Dale D. O. Martin, Michael R. Hayden
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Physiology
Subjects:
huntingtin
HTT
huntington disease
fatty acylation
myristoylation and palmitoylation
post-translational modification (PTM)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1086112/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1086112/full

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