Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue

Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue

The clinical presentation of dengue virus (DENV) infection is variable. Severe complications mainly result from exacerbated immune responses. Type I interferons (IFN-I) are important in antiviral responses and form a crucial link between innate and adaptive immunity. Their contribution to host defen...

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Bibliographic Details
Main Authors: Vinit Upasani, Carolina Scagnolari, Federica Frasca, Nikaïa Smith, Vincent Bondet, Axelle Vanderlinden, Sokchea Lay, Heidi Auerswald, Sothy Heng, Denis Laurent, Sowath Ly, Veasna Duong, Guido Antonelli, Philippe Dussart, Darragh Duffy, Tineke Cantaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
dengue virus
plasmacytoid dendritic cell
myloid dendritic cells
interferon stimulated genes
simoa immunoassay
type I interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.605087/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.605087/full

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