The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies

The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies

Immunoglobulin A nephropathy (IgAN), characterized by mesangial deposition of galactose-deficient-IgA1 (Gd-IgA1), is the most common biopsy-proven primary glomerulonephritis worldwide. Recently, an improved understanding of its underlying pathogenesis and the substantial risk of progression to kidne...

Full description

Bibliographic Details
Main Authors: Chee Kay Cheung, Jonathan Barratt, Adrian Liew, Hong Zhang, Vladimir Tesar, Richard Lafayette
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Nephrology
Subjects:
B-cell activating factor BAFF
a proliferation-inducing ligand APRIL
IgA nephropathy
dual inhibition
atacicept
Online Access:https://www.frontiersin.org/articles/10.3389/fneph.2023.1346769/full

Internet

https://www.frontiersin.org/articles/10.3389/fneph.2023.1346769/full

Similar Items