Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD

Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD

Transactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the brains, spinal cord, and lower motor neurons of affe...

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Bibliographic Details
Main Authors: Tanzeen Yusuff, Ya-Chu Chang, Tzu-Kang Sang, George R. Jackson, Shreyasi Chatterjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Genetics
Subjects:
Drosophila
neurodegeneration
TDP-43
ALS
FTLD
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.881638/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.881638/full

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