Dual functions: A coumarin–chalcone conjugate inhibits cyclic‐di‐GMP and quorum‐sensing signaling to reduce biofilm formation and virulence of pathogens

Dual functions: A coumarin–chalcone conjugate inhibits cyclic‐di‐GMP and quorum‐sensing signaling to reduce biofilm formation and virulence of pathogens

Abstract Antibiotic resistance or tolerance of pathogens is one of the most serious global public health threats. Bacteria in biofilms show extreme tolerance to almost all antibiotic classes. Thus, use of antibiofilm drugs without bacterial‐killing effects is one of the strategies to combat antibiot...

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Bibliographic Details
Main Authors: Yu Zhang, Pramod Bhasme, Dinesh S. Reddy, Dejian Liu, Zhaoxiao Yu, Tianhu Zhao, Yaqian Zheng, Amit Kumar, Haiying Yu, Luyan Z. Ma
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:mLife
Subjects:
biofilm
cyclic‐di‐GMP
exopolysaccharide Psl
Pseudomonas aeruginosa
quorum sensing
Online Access:https://doi.org/10.1002/mlf2.12087

Internet

https://doi.org/10.1002/mlf2.12087

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