Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study

Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study

IntroductionThe BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine.MethodsHere, we dissect the vaccine-induced humoral and cellular responses in a cohort of...

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Main Authors: Sarra Mestiri, Maysaloun Merhi, Varghese P. Inchakalody, Nassiba Taib, Maria K. Smatti, Fareed Ahmad, Afsheen Raza, Fatma H. Ali, Shereena Hydrose, Queenie Fernandes, Abdul W. Ansari, Fairooz Sahir, Lobna Al-Zaidan, Munir Jalis, Mokhtar Ghoul, Niloofar Allahverdi, Mohammed U. Al Homsi, Shahab Uddin, Andrew Martin Jeremijenko, Mai Nimir, Laith J. Abu-Raddad, Fatma Ben Abid, Ahmed Zaqout, Sameer R. Alfheid, Hassan Mohamed Hassan Saqr, Ali S. Omrani, Ali Ait Hssain, Muna Al Maslamani, Hadi M. Yassine, Said Dermime
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19 vaccine
spike-specific immune responses
surrogate neutralization
spike-specific T cells expansion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1061255/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1061255/full

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