ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics

Abstract The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA) plays a crucial role in various DNA metabolic pathways, including DNA replication and repair, by dynamically associating with ssDNA. While the binding of a single RPA molecule to ssDNA has been thoroughly...

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Bibliographic Details
Main Authors: Jiawei Ding, Xiangting Li, Jiangchuan Shen, Yiling Zhao, Shuchen Zhong, Luhua Lai, Hengyao Niu, Zhi Qi
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39579-y