Phospholipid synthesis fueled by lipid droplets drives the structural development of poliovirus replication organelles.

Rapid development of complex membranous replication structures is a hallmark of picornavirus infections. However, neither the mechanisms underlying such dramatic reorganization of the cellular membrane architecture, nor the specific role of these membranes in the viral life cycle are sufficiently un...

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Bibliographic Details
Main Authors: Ekaterina G Viktorova, Jules A Nchoutmboube, Lauren A Ford-Siltz, Ethan Iverson, George A Belov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6128640?pdf=render