Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

Abstract High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical utility in HGSOC. However, the prevalence of C...

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Bibliographic Details
Main Authors: Carolin M. Sauer, James A. Hall, Dominique-Laurent Couturier, Thomas Bradley, Anna M. Piskorz, Jacob Griffiths, Ashley Sawle, Matthew D. Eldridge, Philip Smith, Karen Hosking, Marika A. V. Reinius, Lena Morrill Gavarró, Anne-Marie Mes-Masson, Darren Ennis, David Millan, Aoisha Hoyle, Iain A. McNeish, Mercedes Jimenez-Linan, Filipe Correia Martins, Julia Tischer, Maria Vias, James D. Brenton
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41840-3

Internet

https://doi.org/10.1038/s41467-023-41840-3

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