Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays

Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays

Abstract The DNA damage response (DDR) pathway regulates DNA repair and cell survival, and inactivating mutations in DDR genes can increase tumour mutational burden (TMB), a predictive biomarker of treatment benefit from anti-PD-1/PD-L1 immunotherapies. However, a better understanding of the relatio...

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Bibliographic Details
Main Authors: Danyi Wang, Brian Elenbaas, Karthikeyan Murugesan, Kunal Shah, Meagan Montesion, Ioannis Gounaris, Juergen Scheuenpflug, Giuseppe Locatelli, Zheng Feng
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00442-4

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https://doi.org/10.1038/s41698-023-00442-4

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