Identification and Immune Assessment of T Cell Epitopes in Five Plasmodium falciparum Blood Stage Antigens to Facilitate Vaccine Candidate Selection and Optimization

Identification and Immune Assessment of T Cell Epitopes in Five Plasmodium falciparum Blood Stage Antigens to Facilitate Vaccine Candidate Selection and Optimization

The hurdles to effective blood stage malaria vaccine design include immune evasion tactics used by the parasite such as redundant invasion pathways and antigen variation among circulating parasite strains. While blood stage malaria vaccine development primarily focuses on eliciting optimal humoral r...

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Bibliographic Details
Main Authors: Vinayaka Kotraiah, Timothy W. Phares, Frances E. Terry, Pooja Hindocha, Sarah E. Silk, Carolyn M. Nielsen, Leonard Moise, Kenneth D. Tucker, Rebecca Ashfield, William D. Martin, Anne S. De Groot, Simon J. Draper, Gabriel M. Gutierrez, Amy R. Noe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
malaria
VAC063
class II T cell epitope
RH5
RIPR
CyRPA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.690348/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.690348/full

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