Linked-read based analysis of the medulloblastoma genome

Linked-read based analysis of the medulloblastoma genome

IntroductionMedulloblastoma is the most common type of malignant pediatric brain tumor with group 4 medulloblastomas (G4 MBs) accounting for 40% of cases. However, the molecular mechanisms that underlie this subgroup are still poorly understood. Point mutations are detected in a large number of gene...

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Bibliographic Details
Main Authors: Melissa Zwaig, Michael J. Johnston, John J.Y. Lee, Hamza Farooq, Marco Gallo, Nada Jabado, Michael D. Taylor, Jiannis Ragoussis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
medulloblastoma
linked-reads
enhancer hijacking
extrachromosomal DNA
whole-genome sequencing
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1221611/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1221611/full

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