IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain [version 1; peer review: 2 approved]

IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain [version 1; peer review: 2 approved]

Background:  Cancer is the second leading cause of death globally. Up to 86% of advanced cancer patients experience significant pain, while 10-20% live in chronic pain. Besides, increasing prescription of opioids resulted in 33,000 deaths in the US in 2015. Both reduce patients’ functional status an...

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Main Authors: Mauricio Fernandes, Magdalena Schelotto, Philipp Maximilian Doldi, Giovanna Milani, Abul Andrés Ariza Manzano, Doriam Perera Valdivia, Alexandra Marie Winter Matos, Yasmin Hamdy Abdelrahim, Shaza Ahmed Hamad Bek, Benito K. Benitez, Vanessa Luiza Romanelli Tavares, Abdulrahim M. Basendwah, Luis Henrique Albuquerque Sousa, Naiara Faria Xavier, Tania Zertuche Maldonado, Sarah Toyomi de Oliveira, Melisa Chaker, Michelle Menon Miyake, Elif Uygur Kucukseymen, Kinza Waqar, Ola M.J. Alkhozondar, Ricardo Bernardo da Silva, Guilhermo Droppelmann, Antonio Vaz de Macedo, Rui Nakamura, Felipe Fregni
Format: Article
Language:English
Published: F1000 Research Ltd 2021-01-01
Series:F1000Research
Online Access:https://f1000research.com/articles/10-42/v1

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https://f1000research.com/articles/10-42/v1

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