Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content

Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content

Abstract Background Intervertebral disc degeneration is associated with low back pain, which is a leading cause of disability. While the precise causes of disc degeneration are unknown, inadequate nutrient and metabolite transport through the cartilage endplate (CEP) may be one important factor. Pri...

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Bibliographic Details
Main Authors: Jae‐Young Jung, Mohamed Habib, Luke J. Morrissette, Shannon C. Timmons, Tristan Maerz, Aaron J. Fields
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:JOR Spine
Subjects:
advanced glycation end products
CA4+
cartilage endplate
disc degeneration
glucose uptake
low back pain
Online Access:https://doi.org/10.1002/jsp2.1297

Internet

https://doi.org/10.1002/jsp2.1297

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