The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein

The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein

Many cancers exhibit resistance to chemotherapy, resulting in a poor prognosis. The transcription factor NRF2, activated in response to cellular antioxidants, plays a crucial role in cell survival, proliferation, and resistance to chemotherapy. This factor may serve as a promising target for therape...

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Bibliographic Details
Main Authors: Zhang Dian, Li Jiawen, Zhang Chao, Xue Jinliang, Li Peihao, Shang Kai, Zhang Xiao, Lang Baoping
Format: Article
Language:English
Published: De Gruyter 2024-08-01
Series:Open Life Sciences
Subjects:
nrf2
usp35
deubiquitylation
chemoresistance
esophageal cancer
Online Access:https://doi.org/10.1515/biol-2022-0935

Internet

https://doi.org/10.1515/biol-2022-0935

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