Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection

Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection

Background: HIV infection promotes the expansion of immunosuppressive regulatory T-cells (Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early antiretroviral treatment (ART) upon HIV infection improves CD4 count and decreases immune activation. However, Treg dyn...

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Bibliographic Details
Main Authors: Alexis Yero, Tao Shi, Omar Farnos, Jean-Pierre Routy, Cécile Tremblay, Madeleine Durand, Christos Tsoukas, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:EBioMedicine
Subjects:
HIV
antiretroviral therapy (ART)
regulatory T-cells (Tregs)
FoxP3
TGF-β1
CD39
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003637

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http://www.sciencedirect.com/science/article/pii/S2352396421003637

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