Role of Type I Interferons on Filovirus Pathogenesis

Role of Type I Interferons on Filovirus Pathogenesis

Filoviruses, such as Ebola and Marburg virus, encode viral proteins with the ability to counteract the type I interferon (IFN-I) response. These IFN-I antagonist proteins are crucial to ensure virus replication, prevent an antiviral state in infected and bystander cells, and impair the ability of an...

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Bibliographic Details
Main Authors: Beatriz Escudero-Pérez, César Muñoz-Fontela
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Vaccines
Subjects:
Interferon
filovirus
immune responses
pathogenicity
Online Access:https://www.mdpi.com/2076-393X/7/1/22

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