CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin

CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin

Background/Aims: Though CCR4-NOT2 (CNOT2), one of CCR4-NOT complex subunits, was known to be involved in metastasis and apoptosis through transcription and mRNA degradation, its other biological function is poorly understood so far. The aim of this study is to elucidate the molecular role of CNOT2 i...

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Bibliographic Details
Main Authors: Eun Jung Sohn, Deok-Beom Jung, Jihyun Lee, Sang Wook Yoon, Gun-Ho Won, Hyun Suk Ko, Sung-Hoon Kim
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Adipogenesis
3T3-L1
PPARγ
CEBPα
Obesity
CNOT2
Online Access:http://www.karger.com/Article/FullText/438549

Internet

http://www.karger.com/Article/FullText/438549

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