Structural basis of human TREX1 DNA degradation and autoimmune disease
TREX1 is a cytosolic DNA nuclease and the genetic mutations of it are linked to autoimmune diseases. Here the authors determine the first structure of the human TREX1–DNA complex, and provide a new foundation to explain how patient TREX1 mutations cause autoimmune disease.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32055-z |