Peptides from the Sea Anemone <em>Metridium senile</em> with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors

Peptides from the Sea Anemone <em>Metridium senile</em> with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors

Nicotinic acetylcholine receptors (nAChRs) play an important role in the functioning of the central and peripheral nervous systems, and other organs of living creatures. There are several subtypes of nAChRs, and almost all of them are considered as pharmacological targets in different pathological s...

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Bibliographic Details
Main Authors: Igor E. Kasheverov, Yulia A. Logashina, Fedor D. Kornilov, Vladislav A. Lushpa, Ekaterina E. Maleeva, Yuliya V. Korolkova, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo, Klara Stensvåg, Denis S. Kudryavtsev, Konstantin S. Mineev, Yaroslav A. Andreev
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Toxins
Subjects:
sea anemone venom
<i>Metridium senile</i>
ICK fold peptides
nicotinic acetylcholine receptors
NMR structure
electrophysiology
Online Access:https://www.mdpi.com/2072-6651/15/1/28

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https://www.mdpi.com/2072-6651/15/1/28

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