RIT1 deficiency alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities

RIT1 deficiency alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities

Oligodendrocytes (OLs) generate lipid-rich myelin membranes that wrap axons to enable efficient transmission of electrical impulses. Using a RIT1 knockout mouse model and in situ high-resolution matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) coupled with MS-based l...

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Bibliographic Details
Main Authors: Lei Wu, Fang Wang, Carole L. Moncman, Mritunjay Pandey, Harrison A. Clarke, Hilaree N. Frazier, Lyndsay E.A. Young, Matthew S. Gentry, Weikang Cai, Olivier Thibault, Ramon C. Sun, Douglas A. Andres
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Heliyon
Subjects:
Rit GTPase
Myelin
Oligodendrocyte progenitor cell
Lipidomics
Myelination
Endothelin-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023075928

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http://www.sciencedirect.com/science/article/pii/S2405844023075928

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