Preparation and In Vitro/In Vivo Evaluation of Orally Disintegrating/Modified-Release Praziquantel Tablets

Preparation and In Vitro/In Vivo Evaluation of Orally Disintegrating/Modified-Release Praziquantel Tablets

This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subsequently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate...

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Bibliographic Details
Main Authors: Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan, Xin Deng, Liqin Wu, Qiuling Liang, Fang Fang, Xin Feng, Meiling Yu, Jiakang He
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
praziquantel
hot-melt extrusion
orally integrating tablets
modified-release
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/13/10/1567

Internet

https://www.mdpi.com/1999-4923/13/10/1567

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