Molecular Mechanisms of the Teratogenic Effects of Thalidomide

Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have therapeutic effects in several diseases, although the molecular mechanisms remained unclear. The discovery of cereblon (CRB...

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Bibliographic Details
Main Authors: Tomoko Asatsuma-Okumura, Takumi Ito, Hiroshi Handa
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/13/5/95