Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs

Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs

Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to concomitantly administered drugs that interfere with...

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Bibliographic Details
Main Authors: Jörg König, Martin F. Fromm, Sabine Klatt
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Pharmaceutics
Subjects:
oral antidiabetic drug
organic cation transporter (OCT)
organic anion transporting polypeptide (OATP)
multidrug and toxin extrusion protein (MATE)
ABC (ATP-binding cassette) transporter
P-glycoprotein
drug-drug interaction
Online Access:http://www.mdpi.com/1999-4923/3/4/680/

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http://www.mdpi.com/1999-4923/3/4/680/

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