Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are needed for the more prevalent atrophic (‘dry’) form of...

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Bibliographic Details
Main Authors: Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HDAC6 inhibitors
tubastatin A
retinal degenerations
Hif-1α
proteome profiling
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00689/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00689/full

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