CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b

CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b

Abstract Currently the clinical efficacy of colorectal cancer (CRC) which is the most common malignant tumors over the world has not reached an ideal level. Cetuximab, the monoclonal antibody targeting the extracellular domain of EGFR, has shown its great efficacy in the promotion of apoptosis and t...

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Bibliographic Details
Main Authors: Qi Zhang, Yifeng Zheng, Jiajia Liu, Xiaoxiao Tang, Yuan Wang, Xianzheng Li, Huibin Li, Xiaoying Zhou, Shiru Tang, Yitao Tang, Xiaoyan Wang, Han He, Tingting Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05536-8

Internet

https://doi.org/10.1038/s41419-022-05536-8

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