Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3.

Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3.

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective arterial smooth muscle degeneration. Previous stud...

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Bibliographic Details
Main Authors: He Meng, Xiaojie Zhang, Genggeng Yu, Soo Jung Lee, Y Eugene Chen, Igor Prudovsky, Michael M Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3445613?pdf=render

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http://europepmc.org/articles/PMC3445613?pdf=render

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